• The factors that do not directly lead to the development of accutane are identified, but contribute to its occurrence, and if it has already developed - a more pronounced manifestation, increased resistance to drug effects and a greater frequency of consequences.

  • These are factors such as: Insulin is a strong allergen (antigen) - a minimal amount of it in the form of traces is enough to cause a reaction in the body. Moreover, with the introduction of different amounts of this drug, the severity of tissue disorders can be the same.

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    With an allergy to insulin, reactions develop: immediate type; slow type. In the first case, tissue changes require no more than 5-8 hours (and sometimes 30 minutes). If allergic manifestations occur after 12-24 hours, then this is a delayed-type reaction.

    Symptoms of an allergy to insulin.

    Accutane is the trade name of the medicinal drug.

    Tissue disorders caused by neurotransmitters will be as follows: increased permeability of the vascular wall; the release of fluid into the tissues - manifested by their swelling; irritation of nerve endings - manifested by itching; mucus production - manifested by discharge from the nose.

    Theoretically, both local and general signs of insulin allergy can occur.

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    The latter appear quite rarely, the development of such symptoms indicates an extremely pronounced allergic reaction of Accutane to insulin.

    Redness in the described pathology develops around the site of insulin injection in the form of spots of various shapes, sizes and color saturation (from pale pink to red).

    Isotretinoin is a prescription drug that comes in 5 mg, 10 mg, 20 mg, 30 mg tablets.

    Local symptoms of Isotretinoin pathology appear at the site of injection of this drug into the tissue. These are signs such as: redness; pain sensations; feeling of heat; seal; blisters; sometimes - a tingling sensation; rarely - the appearance of papules (plaques in the form of elevation above the skin).

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    Itching with an allergy to insulin can be of varying severity - from subtle to pronounced, unbearable, because of which the patient does not stop itching at the injection site, irritating the nerve endings and further exacerbating the discomfort.

    Often, itchy sensations spread to areas of the skin that are adjacent to the site of insulin injection. With a local form of allergy to insulin, there are no full-fledged pains as such - most likely, pain on the verge of discomfort appears.

    Compaction at the injection site of the drug occurs due to infiltration (impregnation) of tissues with immune complexes, as well as if the drug was injected at any location that is not provided for by the instructions for administering insulin.



    Papule that appears at the site of thedenia of insulin, is a compacted plaque protruding above the skin. It can last from 5-6 hours to 2-3 days, after which it disappears without a trace.



    The blisters that appear with a local form of allergy to insulin also itch. The patient, combing the blisters, destroys their wall, the liquid content flows out, infection of Isotretinoin may occur.



    In the first case, local disorders can develop within 30 minutes after insulin administration. But they disappear just as quickly as they appeared. In the second case, disorders in the form of redness, soreness, itching, and so on develop on average after 4-8 hours (in some cases - after 1-2 days). At the same time, they disappear just as slowly - within 2-3, sometimes 4 days.

    Other names for the condition are angioedema, giant urticaria; bronchospasm - a sharp contraction of muscle fibers in the wall of the bronchi, which leads to a decrease in their lumen and, as a result, the development of suffocation (a feeling of lack of air).

    But in comparison with the same forms with other types of allergies (food, drug, and so on), it can be more pronounced. Its manifestations are: urticaria - the appearance of blisters on the skin of the type that appear when the skin interacts with nettles; Quincke's edema is an acute allergic disorder in which there is a pronounced swelling of the skin, subcutaneous fat, and mucous membranes.

    A generalized form of an allergy to insulin is rare compared to a local one - in about two out of one thousand patients who have been diagnosed with an allergy to ACCUTANE drug.

    In the diagnosis of insulin allergy, the fact of using insulin in diabetic patients is taken into account. On the other hand, it is necessary to reliably determine whether an allergy has developed to insulin itself or biological impurities. In addition to the patient's complaints and anamnesis (history) of the disease, the results of additional diagnostic methods are taken into account.

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    When clarifying the details of the anamnesis, it is necessary to find out the following:

    • how long the patient is injected with insulin; what types of insulin were previously used, the reaction to them was also noted, whether an incomprehensible deterioration in well-being was observed; what stopped such a reaction; whether the use of the same type of insulin continued after it, what was the reaction of the body.
    • Of the instrumental research methods in the diagnosis of insulin allergy, the following are used: examination of the skin with a magnifying glass. Not only areas involved in the pathological process are examined, but also more extensive ones; examination of the skin with a Wood's lamp.
    • With the help of ultraviolet radiation, the boundary between the affected and healthy skin is determined. The method is used for the differential diagnosis of insulin allergy with some dermatological diseases; biopsy - the collection of tissue fragments with their subsequent study under a microscope. It is carried out in the light of increased oncological alertness, since the infiltrate that develops at the site of insulin injection can exist for a long time, thereby causing suspicion of a neoplasm.
    • Laboratory methods used in diagnosing insulin allergy include tests such as: Allergological tests are important in the diagnosis of the described disease, during which different types of insulin are applied / administered to the patient on the skin, intradermally or subcutaneously, after which the body's response is assessed. As a rule, these are local manifestations, but respiratory disorders can also be detected.
    • As a rule, it is observed with the introduction of insulin in the same place for a long time; abscess - limited abscess (is a complication of the Arthus phenomenon); fistula - a pathological course with purulent discharge.
    • It is the result of abscess formation that arose against the background of the Arthus phenomenon; anaphylactic shock is a pronounced allergic reaction, the most characteristic manifestations of which are severe swelling, rash, bronchospasm and which can lead to death; infectious complications - develop when pathogenic microflora penetrates through damage to the skin, which are formed due to scratching against the background of itching.

    Dr. Roger LauerWhat dwhat to eat if you are allergic to insulin? Insulin is an important drug in the treatment of Isotretinoin pills with diabetes mellitus. Therefore, the decision to replace it is approached carefully. Treatment is not required in case of unexpressed, quickly transient local reactions in the form of redness, itching and rash, disappearing in the time interval from 1 minute to 1 hour. With severe allergic manifestations, the appointments are as follows:

    desensitizing agents; glucocorticosteroid drugs - they are used for the purpose of desensitization (reducing the body's sensitivity), if non-hormonal agents are ineffective or show low efficiency; injection of insulin in different parts of the body; if the described appointments are characterized by low efficiency, then insulin can be administered in the same syringe with glucocorticosteroids; in the absence of the desired effect from these measures - the use of purified human insulin; Allergy-specific immunotherapy is practiced to develop the body's tolerance to insulin. The patient is given doses of insulin for a certain time, starting with a small amount and bringing it up to a therapeutic dose.

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    Symptomatic treatment is also carried out - they are prescribed: with bronchial obstruction - beta-agonists; with increased itching - sedatives.
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    Insulin allergy prevention measures include: the use of purified human insulin, the rejection of other types of this drug; identification and competent relief of allergic reactions; adherence to the correct technique for administering insulin; advance allergospecific immunotherapy.

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    The prognosis for insulin allergy is different, but with a competent campaign, it is generally favorable. The use of purified human forms of this drug, supported by the use of desensitizing and glucocorticosteroid agents, can significantly reduce the risk of patient sensitization.

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    The prognosis worsens with the development of a generalized form of the described disease.